Endodontic treatment is considered one of the most complicated dental treatments. Although we have a general idea about the number of major canals and outline of the roots, but we are dealing with a complex three dimensional system which sometimes happen to be torturous, so we may face difficulties. However, root canal re-treatment would add more difficulties, as more surprises may exist from previous treatment. For that reason, we should gather as mush as possible of information before prompting the treatment, including a comprehensive history taking, thorough clinical examination, proper radiographs, and cone beam CT if needed.